Pharmaceutical Science & Technology

Pharmacological Perspectives of Low Molecular Weight Ligands
Editors: Debarshi Kar Mahapatra, PhD
Sanjay Kumar Bharti, PhD

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Pharmacological Perspectives of Low Molecular Weight Ligands

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The book, Pharmacological Perspectives of Low Molecular Weight Ligands, will focus all fields and classes of drug and drug-technology research aspects, including analytical, drug discovery, computational, synthetic, medicinal, natural products, drug delivery, etc. Low molecular weight ligand interactions with receptor molecules are important for the investigation of biological processes and for drug research.

In this volume, the authors will discuss important chemical/heterocyclic scaffolds and their pharmacological potentials along with identified molecular targets and their inhibitors, pharmaceutical technology, nanotechnology, patents, newer drug delivery techniques, etc. It will cover for the major health-threatening causes, including cancer, diabetes, infectious diseases (microbial and viral), and CVS and CNS ailments, focusing on current therapeutic approaches.

This book will provide a good platform for researchers from diverse fields such as chemical sciences, pharmaceuticals, life sciences, etc. and all interdisciplinary health sciences/applied science researchers.

CONTENTS:
Preface

1. Bedaquiline – The New Anti-Tuberculosis Drug on the Horizon
Gyanshankar P. Mishra

2. Perception of General Anesthetics in Medicine
T. N. V. Ganesh Kumar

3. Perspectives of chalcone based NF-?B inhibitors as anti-inflammatory agents
Debarshi Kar Mahapatra, Vivek Asati, Sanjay Kumar Bharti

4. Pharmacotherapeutic perspectives of adrenergic agonists
Ginpreet Kaur, Erica Sequeira, Harpal S. Buttar, Upendra Nagaich

5. Therapeutic perspectives of adrenergic antagonists
Erica Sequeira, Jaimin Patel, Harpal S. Buttar, Ginpreet Kaur, Upendra Nagaich

6. Skeletal muscle relaxants: concepts and developments
Erica Sequeira, Ginpreet Kaur, Upendra Nagaich

7. Non-steroidal Anti-inflammatory agents: Concepts and Innovations
Upendra Nagaich, Vandana Chaudhary

8. Plant derived natural products as anti-glycating agents
Mobashshera Tariq, Ahmad Ali

9. Low Molecular Weight Anti-oxidant Agents and Model for their Evaluation
Buchi Reddy Purra, Madhusudana Reddy, Animeshchandra G. M. Haldar

10. Drug Metabolism: Detoxification and Xenobiotic Biotransformation
Jayakumar Surendradoss, Alice Varghese, Subrata Deb

11. Drug interactions: Highlights of Adverse Effects of Low Molecular Weight Ligands
Santosh S. Chhajed, Sandeep Sonanwane, Harshala Chaudhari, Aarti Sonar

12. Biological Databases: Tool for Low Molecular Weight Ligand Discovery Process
Santosh Chhajed, Virupaksha A. Bastikar, Pramodkumar P. Gupta, Shital Chaskar

13. High Throughput Screening Technique: Role in the Drug Discovery of Low Molecular Weight Ligands
Santosh S. Chhajed, Parag Pathade

14. Homology modeling: Applications in the Low Molecular Weight Ligand Designing
Santosh S. Chhajed , Pramodkumar P. Gupta, Virupaksha A. Bastikar, Vaibhav Patil

Index


About the Authors / Editors:
Editors: Debarshi Kar Mahapatra, PhD
Assistant Professor, Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India

Debarshi Kar Mahapatra, PhD, is currently Assistant Professor in the Department of Pharmaceutical Chemistry at Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India. He was formerly Assistant Professor in the Department of Pharmaceutical Chemistry, Kamla Nehru College of Pharmacy, RTM Nagpur University, Nagpur, India. He has taught medicinal and computational chemistry at both the undergraduate and postgraduate levels and has mentored students in their various research projects. His area of interest includes computer-assisted rational designing and synthesis of low molecular weight ligands against druggable targets, drug delivery systems, and optimization of unconventional formulations. He has published research, book chapters, reviews, and case studies in various reputed journals and has presented his work at several international platforms, for which he has received several awards by a number of bodies. He has also authored the book titled Drug Design. Presently, he is serving as a reviewer and editorial board member for several journals of international repute. He is a member of a number of professional and scientific societies, such as the International Society for Infectious Diseases (ISID), the International Science Congress Association (ISCA), and ISEI.

Sanjay Kumar Bharti, PhD
Assistant Professor, Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, India

Sanjay Kumar Bharti, PhD, is an Assistant Professor at the Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, India. He has working experience in several organizations, such as Win-Medicare Pvt. Ltd, Meerut, India (as a chemist) and the National Institute of Pharmaceutical Education and Research (NIPER), Hajipur (as a lecturer). He has published several research papers, one book, several book chapters, and several review articles in various reputed journals. His research interest includes synthesis of Schiff’s base, heterocyclic compounds, and metallopharmaceuticals for therapeutics. He is an active member of various scientific and pharmaceutical organizations, like the Indian Pharmaceutical Association, Indian Pharmacy Graduates’ Association, Indian Science Congress Association, among others. Dr. Bharti has received his BPharm degree from Indian Institute of Technology (IIT-BHU), Varanasi, his MPharm degree from Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India, and his PhD from IIT-BHU, Varanasi, India.




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