Biomedical Engineering/Nanotechnology

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications
Editor: Raquel Cumeras, PhD
Xavier Correig, PhD

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications

Published. Available now.
Pub Date: November 2018
Hardback Price: See Ordering info
Hard ISBN: 9781771887441
Paperback ISBN: 978-1-77463-426-4
E-Book ISBN: 9780429433580
Pages: 292pp w/ index
Binding Type: hardbound / ebook / paperback
Notes: 12 color and 38 b/w illustrations

Now Available in Paperback


This volume, Volatile Organic Compound Analysis in Biomedical Diagnosis Applications, presents a thought-provoking state-of-the-art picture of how volatile compounds are used in metabolomics, currently a hot topic in the metabolomics field. It provides a thorough description of what are volatile organic compounds (VOCs), why are they important in biomedicine, and what are the analytical platforms used. It also looks at multivariate analysis and databases needs.

Volatile organic compounds (VOCs) are gaining considerable interest for their unique ability to provide insight into underlying mechanisms of physiological and pathophysiological processes. New research looks at ways to exploit concentration profiles of VOCs in biological sources for disease detection and for therapeutic monitoring of treatment regimens. As a biochemical probe, VOCs are special because they can provide both non-invasive and continuous information on the metabolic/physiological state of an individual. In humans, VOCs are found in exhaled breath and in a broad variety of biofluids, like urine, blood, tissue, skin emanations, saliva, and feces. Detection and confirmation of VOCs as biomarkers may be additionally complicated by the fact that VOC levels are linked to metabolic processes.

This new volume explains why volatiles are important compounds in biomedical diagnosis and how researchers detect and analyze them. Because they are end-up compounds of metabolic processes, volatiles can be linked to different diseases or pathologies for both diagnosis and prognosis. The authors provide authoritative information and guidance on the analytical and statistical techniques used and how to identify and review the main current areas of application, which include breath metabolomics, cancer diagnosis, and microbial volatiles.

This volume will be of interest to analytical scientists and to those working in application areas as diverse human clinical medicine and environmental science as well as to point-of-care medicine researchers.

Key features:
  • Presents a thorough overview of volatile research in biomedical applications
  • Examines both gold standard techniques (metabolomics based) and artificial olfactory systems
  • Reviews all aspects of volatile metabolites in biomedicine research, from origin to detection platforms
  • Describes relevant diseases diagnosis and prognosis achievements, including cancer

CONTENTS:
Preface

PART I: VOLATILES AND DETECTION TECHNOLOGIES
1. The Volatilome in Metabolomics
Raquel Cumeras

2. Basics of a Gas Chromatography Mass Spectrometry System
William Hon Kit Cheung and Raquel Cumeras

PART II: BIOMEDICAL DIAGNOSIS APPLICATIONS
3. Analysis of Volatile Organic Compounds for Cancer Diagnosis
A. V. Rutter and J. Sulé-Suso

4. Artificial Olfactory Systems Can Detect Unique Odorant Signature of Cancerous Volatile Compounds
Radu Ionescu

5. Bottom-Up Cell Culture Models to Elucidate Human In Vitro Biomarkers of Infection
Michael Schivo, Mitchell M. McCartney, Mei S Yamaguchi, Eva Borras, and Cristina E. Davis

6. Characterizing Outdoor Air Using Microbial Volatile Organic Compounds (MVOCs)
Sonia Garcia-Alcega and Frédéric Coulon

7. Breathomics and Its Application for Disease Diagnosis: A Review of Analytical Techniques and Approaches
David J Beale, Oliver A. H. Jones, Avinash V. Karpe, Ding Y. Oh, Iain R. White, Konstantinos A. Kouremenos, and Enzo A. Palombo

PART III: COMPUTATIONAL TOOLS
8. The Need for External Validation for Metabolomics Predictive Models
Raquel Rodríguez-Pérez, Marta Padilla, and Santiago Marco

9. Insight into KNApSAcK Metabolite Ecology Database: A Comprehensive Source of Species-VOC-Biological Activity Relationships
Azian Azamimi Abdullah, Md. Altaf-Ul-Amin, and Shigehiko Kanaya

Index


About the Authors / Editors:
Editor: Raquel Cumeras, PhD
Director of Research, STARTING GRANT from Martí Franquès Programme at Universitat Rovira i Virgili, Tarragona, Catalonia, Spain

Raquel Cumeras, PhD, has received a Starting Grant from the Programa Martí Franquès at the University Rovira i Virgili (URV, Tarragona, Catalonia, Spain) in 2017 to identify reliable and specific urinary bladder cancer biomarkers using metabolomics and crosslinking them with other urinary cancers (prostate and kidney). She has a broad knowledge in pre-concentration methods and sensors and analytical chemistry for volatile compounds, including standard techniques such as GC-MS but also gas sensors based in ion mobility spectrometry sensors. The high quality of her research has been widely proven as she was awarded with a postdoctoral starting grant, her PhD thesis received the Outstanding PhD thesis award, and also the results of her research have been published in high-standard peer-reviewed scientific journals. She has recently submitted a new paper on metabolomics analysis as first author and a review of VOCs. After completing her PhD, Dr. Cumeras spent two years as postdoctoral researcher at the University of California Davis, and after a sabbatical year for maternity, she was a postdoc at the Institute of Bioengineering of Catalonia (IBEC, Barcelona, Catalonia, Spain). Currently, her own research is focused not only on the development of metabolomics studies for determining volatile biomarkers but also on cancer metabolomics studies using the less invasive samples as breath, urine, blood, and feces.

Xavier Correig, PhD
Full Professor, Department of Electronic Engineering, Universitat Rovira i Virgili, Tarragona, Catalonia, Spain

Xavier Correig, PhD, is a Full Professor at the Universitat Rovira i Virgili (URV, Tarragona, Catalonia, Spain) and has extensive experience in training and research at the Department of Electronic Engineering. He created and coordinated the Metabolomics Platform (http://metabolomicsplatform.com/), a research infrastructure created by the URV and the CIBERDEM (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas). With more than 10 years of experience in the field, he is an expert on metabolomics, especially in NMR spectroscopy and mass spectrometry imaging. Professor Correig has published more than 200 articles, supervised several PhD students, and created a spin-off company, Biosfer Teslab, which is commercializing the Liposcale Test (a novel advanced lipoprotein test based on 2D diffusion-ordered 1H NMR spectroscopy). He has also experience for more than 20 years in gas sensing and electronic nose based on metal oxides sensors or MS.




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