Medicine & Health Sciences

Sleep, Circadian Rhythms, and Metabolism
The Rhythm of Life

Editor: William Olds

Sleep, Circadian Rhythms, and Metabolism

2014. Available now.
Pub Date: 
Hardback Price: $159.95 US
Hard ISBN: 9781771880626
E-Book ISBN: 978-1-4822-6265-0
Pages: 378 pages with index
Binding Type: hardbound

This title includes a number of Open Access chapters.

Providing a nuanced study of the connections between sleep, circadian rhythms, and metabolism, this informative book examines how circadian actions affect the liver and adipose tissue, the brain, and metabolism. This important book introduces the reader to circadian rhythms in the body and the external cues which set them, discusses on a molecular and organ level how disrupting these clocks results in metabolic and sleep disorders, and looks at the clinical applications of circadian rhythms, with a focus on sleep.

The book covers a variety of important research in the field, including:
  • the power of computational biology to uncover new nodes in the network of circadian rhythms
  • circadian rhythms as they relates to obesity
  • how late-night shift conditions impairs the body’s ability to keep time and promote metabolic diseases and how this can be mitigated by strategic planning of feeding times
  • the relationship between the suprachiasmatic nuclei and orexin neurons, demonstrating the elegant interplay between our biological clocks and wakefulness
  • how sleep disorders can result from irregular circadian rhythms and potential ways to diagnose this in individuals
  • how sleeping behaviors can disturb the hypothalamic-pituitary-adrenal axis and the repercussions of this disruption on female reproduction
  • how disruption of sleep can be clinically beneficial for depressed patients
  • how mental state is influenced by circadian rhythm
  • more

Part I: Introduction: The Watch Inside all of Us
Chapter 1. Regulation of Prokineticin 2 Expression by Light and the Circadian Clock
Michelle Y. Cheng, Eric L. Bittman, Samer Hattar, and Qun-Yong Zhou
Chapter 2. Circadian Signatures in Rat Liver: From Gene Expression to Pathways
Meric A. Ovacik, Siddharth Sukumaran, Richard R. Almon, Debra C. DuBois, William J. Jusko, and Ioannis P. Androulakis
Chapter 3. Body Weight, Metabolism, and Clock Genes
Melissa M. Zanquetta, Maria Lúcia Corrêa-Giannella, Maria Beatriz Monteiro, and Sandra M.F. Villares
Part II: Metabolism at Night versus the Morning
Chapter 4. Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork
Johanna L. Barclay, Jana Husse, Brid Bode, Nadine Naujokat, Judit Meyer-Kovac, Sebastian M. Schmid, Hendrik Lehnert, and Henrik Oster
Chapter 5. Circadian Rhythms and Obesity in Mammals
Oren Froy
Chapter 6. Food and the Circadian Activity of the Hypothalamic-Pituitary-Adrenal Axis
A. M. O. Leal and A. C. Moreira
Chapter 7. Circadian and Dark-Pulse Activation of Orexin/Hypocretin Neurons
Oliver J. Marston, Rhîannan H. Williams, Maria M. Canal, Rayna E. Samuels, Neil Upton, and Hugh D. Piggins
Chapter 8. Meal Time Shift Disturbs Circadian Rhythmicity Along with Metabolic and Behavioral Alterations in Mice
Ji-Ae Yoon, Dong-Hee Han, Jong-Yun Noh, Mi-Hee Kim, Gi Hoon Son, Kyungjin Kim, Chang-Ju Kim, Youngmi Kim Pak, and Sehyung Cho
Chapter 9. A Metabolic–Transcriptional Network Links Sleep and Cellular Energetics in the Brain
Jonathan P. Wisor
Part III: Effects of Artificial Light and Sleep Disruption on Metabolism
Chapter 10. Pathophysiology and Pathogenesis of Circadian Rhythm Sleep Disorders
Akiko Hida, Shingo Kitamura, and Kazuo Mishima
Chapter 11. Shift Work, Jet Lag, and Female Reproduction
Megan M. Mahoney
Chapter 12. A New Approach to Understanding the Impact of Circadian Disruption on Human Health
Mark S. Rea, Andrew Bierman, Mariana G. Figueiro, and John D. Bullough
Chapter 13. Waking and Sleeping in the Rat Made Obese Through a High-Fat Hypercaloric Diet
Marco Luppi, Matteo Cerri, Davide Martelli, Domenico Tupone, Flavia Del Vecchio, Alessia Di Cristoforo, Emanuele Perez, Giovanni Zamboni, and Roberto Amici
Chapter 14. Effect of Sleep Deprivation on Brain Metabolism of Depressed Patients
Joseph C. Wu, J. Christian Gillin, Monte S. Buchsbaum, Tamara Hershey, J. Chad Johnson, and William E. Bunney, Jr.

About the Authors / Editors:
Editor: William Olds
Molecular Cell Biology, Genetics and Development, Yale University, New Haven, Connecticut, USA

William Olds has an undergraduate degree from University of Michigan and is working on his graduate degree at Yale University, New Haven, Connecticut, USA, in the laboratory of Tian Xu. His current research focuses on satiety signals from the gut and how that communication to the brain breaks down in the pathogenesis of obesity.

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