Investigations in Yeast Functional Genomics and Molecular Biology
Editor: Matthew Eckwahl, MPhil

Investigations in Yeast Functional Genomics and Molecular Biology

Published. Available now.
Pub Date: March 2014
Hardback Price: $149.95 US
Hard ISBN: 9781771880107
E-Book ISBN: 9781482240962
Pages: 412pp
Binding Type: hardbound

This title includes a number of Open Access chapters.

This book presents readers with a range of topics that showcase the advantages of the complex biological phenomena of yeast. The first section deals with symmetry breaking, a fundamental process in biology. The book also looks at another important developmental transition in yeast—the switch to a filamentous growth form. Yeast helps us understand mechanisms of prion formation and transmission as well as possible biological roles. Many of the chapters presented also highlight the power of yeast in addressing genomewide problems in biology. Along these lines, chapters also introduce the reader to the rapidly expanding field of comparative genomics, which not only helps tease apart evolutionary kinship but also aids the discovery of functional elements throughout a genome.

This book will inform the reader of a variety of interesting studies undertaken in yeast, employing a broad range of methodology from mathematical modeling to next-generation sequencing. This book:
  • examines conserved pathways mediating cell cycle progression and cell polarity establishment
  • discusses examples of yeast regulatory circuits and feedback regulation, with emphasis on system-wide approaches
  • covers protein interaction networks and trait locus analysis
  • presents methods and challenges in comparative genomics analysis and evolutionary genetics

Part I: Cell Polarity, Growth, and Cell Cycle

Chapter 1. Daughter-Specific Transcription Factors Regulate Cell Size Control in Budding Yeast

Stefano Di Talia, Hongyin Wang, Jan M. Skotheim, Adam P. Rosebrock, Bruce Futcher, and Frederick R. Cross

Chapter 2. Modeling Robustness Tradeoffs in Yeast Cell Polarization Induced by Spatial Gradients

Ching-Shan Chou, Qing Nie, and Tau-Mu Yi

Chapter 3. Multisite Phosphorylation of the Guanine Nucleotide Exchange Factor Cdc24 during Yeast Cell Polarization

Stephanie C. Wai, Scott A. Gerber, and Rong Li
Part II: Yeast Regulatory Circuits

Chapter 4. Roles of Candida albicans Gat2, a GATA-Type Zinc Finger Transcription Factor, in Biofilm Formation, Filamentous Growth and Virulence

Han Du, Guobo Guan, Jing Xie, Yuan Sun, Yaojun Tong, Lixin Zhang, and Guanghua Huang

Chapter 5. Deciphering Human Heat Shock Transcription Factor 1 Regulation via Post-Translational Modification in Yeast

Liliana Batista-Nascimento, Daniel W. Neef, Phillip C. C. Liu, Claudina Rodrigues-Pousada, and Dennis J. Thiele

Chapter 6. Environmental Regulation of Prions in Yeast

Liming Li and Anthony S. Kowal

Chapter 7. Heterologous Gln/Asn-Rich Proteins Impede the Propagation of Yeast Prions by Altering Chaperone Availability

Zi Yang, Joo Y. Hong, Irina L. Derkatch, and Susan W. Liebman
Part III: Gene Expression and Trait Locus Analysis

Chapter 8. Strategy of Transcription Regulation in the Budding Yeast

Sagi Levy, Jan Ihmels, Miri Carmi, Adina Weinberger, Gilgi Friedlander, and Naama Barkai

Chapter 9. A Screen for RNA-Binding Proteins in Yeast Indicates Dual Functions for Many Enzymes

Tanja Scherrer, Nitish Mittal, Sarath Chandra Janga, and André P. Gerber

Chapter 10. Genetic Landscape of Open Chromatin in Yeast

Kibaick Lee, Sang Cheol Kim, Inkyung Jung, Kwoneel Kim, Jungmin Seo, Heun-Sik Lee, Gireesh K. Bogu, Dongsup Kim, Sanghyuk Lee, Byungwook Lee, and Jung Kyoon Choi
Part IV: Comparative Genomics

Chapter 11. High Quality de novo Sequencing and Assembly of the Saccharomyces arboricolus Genome

Gianni Liti, Alex N. Nguyen Ba, Martin Blythe, Carolin A. Müller, Anders Bergström, Francisco A. Cubillos, Felix Dafhnis-Calas, Shima Khoshraftar, Sunir Malla, Neel Mehta, Cheuk C. Siow, Jonas Warringer, Alan M. Moses, Edward J. Louis, and Conrad A. Nieduszynski

Chapter 12. Comparative Gene Expression Between Two Yeast Species

Yuanfang Guan, Maitreya J. Dunham, Olga G. Troyanskaya, and Amy A. Caudy

Chapter 13. Whole-Genome Comparison Reveals Novel Genetic Elements That Characterize the Genome of Industrial Strains of Saccharomyces cerevisiae

Anthony R. Borneman, Brian A. Desany, David Riches, Jason P. Affourtit, Angus H. Forgan, Isak S. Pretorius, Michael Egholm, and Paul J. Chambers


About the Authors / Editors:
Editor: Matthew Eckwahl, MPhil
Department of Cell Biology, Yale University, New Haven, Connecticut, USA

Matthew Eckwahl, MPhil, is a current graduate student at Yale University in the Department of Cell Biology, New Haven, Connecticut, where he is a NSF Graduate Research Fellow. He received his BS in molecular biology and biotechnology at the University of Michigan-Flint. Mr. Eckwahl has research experience in regulatory networks of psuedohyphal growth response and is currently working on the packaging of non-coding RNA by retroviruses.

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