Epigenetics and Pathology
Exploring Connections Between Genetic Mechanisms and Disease Expression

Editor: Kasirajan Ayyanathan, PhD

Epigenetics and Pathology

Published. Available now.
Pub Date: November 2013
Hardback Price: $169.95 US
Hard ISBN: 9781926895789
E-Book ISBN: 9781482224825
Pages: 424pp
Binding Type: hardbound

This title includes a number of Open Access chapters.

This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including:
  • host-pathogen interactions
  • causal relationships between genes and the environment
  • the effects of environmental chemicals on gene expression
  • DNA methylation
The book also covers the analysis and provides models for understanding the epigenetics-pathology connection.

This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.

Chapter 1. Epigenetics of Host-Pathogen Interactions: The Road Ahead and the Road Behind
Elena Gómez-Díaz, Mireia Jordà, Miguel Angel Peinado, and Ana Rivero

Chapter 2. A Concise Review on Epigenetic Regulation: Insight into Molecular Mechanisms

Shahram Golbabapour, Mahmood Ameen Abdulla, and Maryam Hajrezaei

Chapter 3. Genome Wide Analysis of DNA Methylation in Human Amnion

Jinsil Kim, Mitchell M. Pitlick, Paul J. Christine, Amanda R. Schaefer, Cesar Saleme, Belén Comas, Viviana Cosentino, Enrique Gadow, and Jeffrey C. Murray

Chapter 4. Assessing Causal Relationships in Genomics: From Bradford-Hill Criteria to Complex Gene-Environment Interactions and Directed Acyclic Graphs

Sara Geneletti, Valentina Gallo, Miquel Porta, Muin J. Khoury, and Paolo Vineis

Chapter 5. The Biology of Lysine Acetylation Integrates Transcriptional Programming and Metabolism

Jigneshkumar Patel, Ravi R. Pathak, and Shiraz Mujtaba

Chapter 6. Roles of Histone Deacetylases In Epigenetic Regulation: Emerging Paradigms from Studies with Inhibitors

Geneviève P. Delcuve, Dilshad H. Khan, and James R. Davie

Chapter 7. Aberrant Epigenetic Silencing Is Triggered by a Transient Reduction in Gene Expression

Jon A. Oyer, Adrian Chu, Sukhmani Brar, and Mitchell S. Turker

Chapter 8. The Sound of Silence: Rnai In Poly (ADP-Ribose) Research

Christian Blenn, Philippe Wyrsch, and Felix R. Althaus

Chapter 9. Epigenetic Deregulation of Micrornas in Rhabdomyosarcoma and Neuroblastoma and Translational Perspectives

Paolo Romania, Alice Bertaina, Giorgia Bracaglia, Franco Locatelli, Doriana Fruci, and Rossella Rota

Chapter 10. Epigenetic Effects of Environmental Chemicals Bisphenol A and Phthalates

Sher Singh and Steven Shoei-Lung Li

Chapter 11. The Influence of DNA Sequence on Epigenome-Induced Pathologies

Richard B Meagher and Kristofer J MüSsar

Chapter 12. Next Generation Sequencing Based Approaches to Epigenomics

Martin Hirst and Marco A. Marra

Chapter 13. Design and Analysis Issues in Gene and Environment Studies

Chen-Yu Liu, Arnab Maity, Xihong Lin, Robert O. Wright, and David C Christiani

Appendix 1: Using Austin Bradford Hill’s Guidelines in Genetics and Genomics

Sara Geneletti, Valentina Gallo, Miquel Porta, Muin J. Khoury, and Paolo Vineis

Appendix 2: The Calculus of the Decision Theoretic Framework (DTF)

Sara Geneletti, Valentina Gallo, Miquel Porta, Muin J. Khoury, and Paolo Vineis

Appendix 3: Parkinson’s Disease: Environmental and Genetic Risk Factors

Sara Geneletti, Valentina Gallo, Miquel Porta, Muin J. Khoury, and Paolo Vineis


About the Authors / Editors:
Editor: Kasirajan Ayyanathan, PhD
Research Associate Professor, Center for Molecular Biology and Biotechnology, Florida Atlantic University

Kasirajan Ayyanathan received his PhD degree from the Department of Biochemistry, Indian Institute of Science, one of the premier research institutions in India. Subsequently, at Temple University School of Medicine, USA, he conducted post-doctoral research on the signal transduction by purinergic receptors, a class of G-Protein Coupled Receptors (GPCR), in erythroleukemia cancer cells. Next, he was trained as a staff scientist at the Wistar Institute, USA for almost ten years and studied transcription regulation, chromatin, and epigenetic regulatory mechanisms in cancer before becoming an Associate Professor at Florida Atlantic University (FAU). Currently he is at the Center for Molecular Biology and Biotechnology as a Research Associate Professor at FAU. He is the recipient of Chern memorial award and Howard Temin career research award. Dr. Ayyanathan is well trained in molecular biology, cell biology, and biochemistry with main focus on studying transcription factors and gene regulation. Dr. Ayyanathan has published several research articles in peer-reviewed journals.

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